We are living in an era where biology has become synonymous with big data due to the ever-increasing amount of data being generated by technologies such as next-generation sequencing. Bioinformatics ...

Multiple sequence alignment (MSA) is a cornerstone of computational biology, facilitating the exploration of functional, structural and evolutionary relationships among biological sequences.

The classic methodology of inferring a phylogenetic tree from sequence data is composed of two steps. First, a multiple sequence alignment (MSA) is computed. Then, a tree is reconstructed assuming the ...

Many cellular processes, including transcription and DNA replication, critically depend on chromatin structure, the three-dimensional organization of DNA that includes nucleosome positioning and ...