导读人类胚胎常在受精后至着床前的关键发育节点停滞，导致不孕和妊娠丢失等临床问题。受精卵形成后，合子基因组激活(ZGA)是胚胎发育经历的第一个关键节点。此时，胚胎逐步脱离对母体RNA和蛋白质的依赖，向合子基因自主表达模式过渡。ZGA异常是导致人类早期胚 ...

New findings offer insight into why some embryos fail to develop past zygotic genome activation (ZGA), pointing to an unexpected root of human infertility. A critical point in early development is ...

New findings offer insight into why some embryos fail to develop past zygotic genome activation (ZGA), pointing to an unexpected root of human ...

A stretch of viral DNA in the mouse genome gives cells in early-stage embryos the potential to become almost any cell type in ...

A new "atlas" of early embryonic development in mammals suggests that the process is highly chaotic — but there is some method to the madness. When you purchase through links on our site, we may earn ...

The oviduct plays an indispensable role in mammalian reproduction by not only transporting gametes and embryos but also by providing a finely tuned microenvironment that supports fertilisation and ...

In the earliest hours after fertilization, an embryo takes its first steps toward becoming a living organism by shedding maternal control and activating its own genetic program. This critical process, ...

Biologists have provided new insights on a longstanding puzzle in biology: How complex organisms arise from a single fertilized cell. Producing a new 'gene atlas' with 4-D imaging, the researchers ...

Cell division is an essential process for all life on Earth, yet the exact mechanisms by which cells divide during early embryonic development have remained elusive—particularly for egg-laying species ...

A research team showed that, contrary to current models, one early embryonic cell dominates lineages that will become the fetus. “They are not identical,” said Magdalena Zernicka-Goetz, a ...