A study recently published in the Journal of Cell Biology has demonstrated the endosomal transport process of nanoparticle-based formulations that leads to the effective delivery of messenger ...

Endosomal stress, the aberrant accumulation of K63 ubiquitin chains on dysfunctional endosomes, activates the TAB2/3–TAK1–NF-kB and p62–Keap1–Nrf2 pathways, resulting in the expression of immune and ...

Protein-based drugs must be transported into cells in a way that prevents their immediate degradation. A new approach is intended to ensure that they remain intact only in certain cells, such as ...

Researchers at New York University Pain Research Center have identified a mechanism that underlies inflammation and pain in the colon, and demonstrated that in mice with colitis, blocking a key ...