In vertebrates, large exons often skip splicing events and are evolutionarily conserved. Scientists have recently identified the mechanism behind regulated splicing of large constitutive exons which ...

In vertebrates, large exons often skip splicing events and are evolutionarily conserved. Scientists from Nagoya University, Japan, led by Associate Professor Akio Masuda, have recently identified the ...

These findings demonstrate that PTBP1 can regulate cassette exon splicing via mediating specific RNA loops in a position-dependent manner. According to minigene-based analysis, the researchers found ...

Neoantigen screening identifies EGFR L858R mutation immunogenicity in 1862 Chinese NSCLC patients. Using real-world data to investigate time-dependent blood count response to PD-1 and PD-L1 inhibitors ...

"While analyses to date have identified few splicing regulators with prognostic implications in pancreatic cancer, the incidence of exon splicing events conserved across pancreatic tumors and other ...

Many sequences found within mammalian introns closely resemble the specific 5' and 3' splice site consensus signals that regulate exon splicing. It is unclear how the real splice sites are selected ...

Clinical Nomogram Using Novel Computed Tomography–Based Radiomics Predicts Survival in Patients With Non–Small-Cell Lung Cancer Treated With Stereotactic Body Radiation Therapy Colorectal cancer (CRC) ...

In TDP-43 proteinopathies, the RNA/DNA binding protein leaves its post in the nucleus and travels to cytosol, where it’s prone to aggregate. This meandering allows mis-spliced transcripts to ...

This article was review by Thomas Cooper, MD from Baylor College of Medicine. Stay up to date on the latest science with Brush Up Summaries. Despite its significance, alternative splicing’s global ...