为探究溃疡性结肠炎（UC）中肠上皮细胞凋亡及屏障破坏机制，研究人员开展了 HSP75 对线粒体通透性转换孔（mPTP）调节作用的研究。结果发现 HSP75 在 UC 患者肠黏膜中显著降低，可调节 mPTP 开启，影响细胞凋亡和肠上皮屏障。这为 UC 治疗提供新方向。 在人体的 ...

本期推荐：中科院团队通过三维行为分析平台结合机器学习，揭示了MPTP诱导的SNc（黑质致密部）而非VTA（腹侧被盖区）DA神经元缺失特异性导致小鼠攀爬、弓背等行为缺陷及运动侧化现象，为帕金森病早期行为标志物发现提供了新范式。研究发表于《Translational ...

黑质致密部（SNpc）多巴胺能神经元丢失是帕金森病最明显的病理改变，但相邻的腹侧被盖区（VTA）的多巴胺能神经元却无明显变化。因此，研究人员们不禁提出这样一个问题——为什么在SNpc中的多巴胺能神经元比在VTA中的更脆弱？ 已有的研究显示，钙稳态的 ...

脑声小店基于深度科研洞察，专注为动物实验提供"简器械·精实验"解决方案。我们突破高精设备局限，开发手工定制化仪器及配件，通过科研巧思将基础工具转化为创新实验方案。产品涵盖行为学装置、操作辅助工具等，使实验室在保持操作简效的同时，实现 ...

Increasing evidence suggests that apoptosis may be the mechanism underlying cell death in selective loss of nigral dopaminergic neurons in Parkinson's disease (PD). Previous studies strongly suggested ...

Until five years ago, scientists investigating Parkinson’s disease were frustrated in their attempts to unravel the biochemical mechanism of this debilitating disease. Lacking an animal model, they ...

Department of Anatomy and Neurobiology, Northeast Ohio Medical University (NEOMED), College of Medicine, Rootstown, OH School of Biomedical Sciences, Kent State University, Kent, OH Environmental ...

In a mouse model of early Parkinson's disease (PD), animals displayed movement deficits, loss of tyrosine-hydroxylase (TH)-positive fibers in the striatum, and astro-gliosis and micro-gliosis in the ...