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生物通
1月
PolyA_DB v4:基于3'端与长读长测序数据系统鉴定人鼠基因组多聚腺苷 ...
本研究针对真核生物mRNA和lncRNA 3'末端多聚腺苷酸化位点(PAS)注释不全面、存在内部引物伪影等问题,开发了PolyA_DB v4数据库。团队通过深度挖掘364个人类与451个小鼠3'READS+数据集(约23亿条PAS支持 reads),结合长读长RNA测序(LR-RNA-seq)验证,分别鉴定出142.9万(人 ...
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