引言在肿瘤生物学的浩瀚星空中，如果说有一个名字如同“皇帝”般存在，那非 MYC 莫属。作为最著名的致癌基因之一，MYC在超过 70% 的人类癌症中处于过度表达或突变状态。几十年来，教科书告诉我们：它是一个超级转录因子（Transcription ...

本研究针对胶质母细胞瘤(GBM)如何维持R-loop稳态以平衡转录需求与基因组稳定性这一关键问题，揭示了THOC1通过与SIN3A组蛋白去乙酰化复合物相互作用，特异性调控端粒区R-loop水平的新机制。研究人员发现靶向THOC1可破坏端粒稳定性，显著抑制GBM进展，为这一难治 ...

Dysregulated R-loops can cause stalled replication forks and telomere instability. However, how R-loops are recognized and regulated, is still not well understood, particularly at telomeres. In this ...

This new review article highlights the pivotal and paradoxical role of R-loops in maintaining genomic stability while simultaneously posing risks to it. These three-stranded nucleic acid structures, ...

Image Caption: The factors contributing to R-loop formation. Several factors contribute to R-loop formation, including RNA components, specific DNA structures, histone and RNA modifications, ...

A look at neurodegenerative disease in the context of the aging brain will test the link between peculiar genomic structures in the cells, called R-loops, known to cause DNA damage as we age and ...

Kyle Miller and his team discovered a potential new target for drug therapies: structures in our DNA called R-loops. A human cancer cell that overexpresses the enzyme APOBEC3B (left) has fewer R-loops ...

“There are currently limited therapeutic options for elderly patients with myeloid malignancies, who are ineligible for stem cell transplantation,” commented Dr. Sayantani Sinha, a postdoctoral ...

Genetically speaking, it's a bacterium's worst-case scenario: During transcription, newly minted RNA sticks to its DNA template, forming a 3-stranded structure known as an R-loop. While these ...

Our immune systems are remarkably adept at sounding the alarm when something goes wrong—sometimes even to the point of overreacting. But what happens when a notorious oncoprotein like MYC learns to ...