Medscape

Etravirine: A Novel Nonnucleoside Reverse Transcriptase Inhibitor for Managing Human Immunodeficiency Virus Infection

Purpose: The pharmacology, efficacy, and safety of etravirine and its clinical utility with respect to the available alternative human immunodeficiency virus (HIV) treatment options are reviewed.
The Lancet

Beyond integrase: the rise of doravirine and islatravir in HIV management

Combination antiretroviral therapy (ART) has transformed HIV-1 infection into a chronic condition with near-normal life expectancy. For more than two decades, the standard regimen has been a ...
Nature

HIV-1 Reverse Transcriptase and Integrase Inhibitors

The inhibition of HIV-1’s replicative machinery remains a cornerstone in the battle against AIDS. Central to this approach are inhibitors targeting reverse transcriptase (RT) and integrase. Reverse ...
Infectious Disease Advisor

Switch to INSTI+NRTI ART Regimens Highly Effective in Virologically Suppressed HIV

Switching to a 2-drug ART regimen was highly effective and well tolerated in virologically suppressed patients with HIV.
Medscape

Nucleoside and Nucleotide Reverse Transcriptase Inhibitors in Children

Clin Drug Invest. 2007;27(8):509-531. Antiretroviral drugs (ARVs) can be divided into four different classes according to their modes of action: nucleoside or nucleotide reverse transcriptase ...
Business Insider

ROME Therapeutics Debuts First Preclinical Data of its LINE-1 Reverse Transcriptase (RT) Inhibitors in Neurodegenerative Diseases at 3rd Annual Dark Genome Symposium

BOSTON, Nov. 21, 2024 (GLOBE NEWSWIRE) -- ROME Therapeutics, a biotechnology company illuminating the intersection of the dark genome and innate immunity to develop breakthrough medicines for ...
Clinical Advisor

Long-Acting ART Possible Therapeutic Option for HIV With Prior HBV Exposure

Researchers examined the incidence of hepatitis B reactivation and incident infection after switching to long-acting cabotegravir plus rilpivirine among patients with HIV.
Medical Xpress

NRTI use linked to risk for primary open-angle glaucoma

Use of nucleoside and nucleotide reverse transcriptase inhibitors (NRTIs) is associated with an increased risk for primary open-angle glaucoma (POAG), according to a study published online June 20 in ...
News Medical

Reverse transcriptase activity found in aging and Alzheimer’s brains

Alzheimer's disease is the most common cause of dementia and affects more than a tenth of Americans aged 65 and older. The disease has proven difficult to develop new treatments for, and available ...
The Scientist

Thermostable Reverse Transcriptase at Room Temperature

New England Biolabs (NEB®) announced today that they have released a novel, thermostable reverse transcriptase, WarmStart® RTx Reverse Transcriptase, specifically designed for nucleic acid detection.
Nature

HIV-1 Reverse Transcriptase Inhibitors

HIV-1 reverse transcriptase inhibitors have long been central to antiretroviral therapy, effectively impeding the enzyme responsible for converting viral RNA into DNA – a pivotal step in HIV ...