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“爱”的是它作为中等强度（Moderate）证据，对VUS升级至关重要；“恨”的是到底什么是“热点”？除了少数几个VCEP（变异专家组）定义过的区域，大多数基因的PM1应用全靠“拍脑袋”，缺乏一个系统、可量化的数据库。