🎯 Beyond MAP: Optimizing Tissue Perfusion Pressure in Sepsis 🩸 Optimizing macrohemodynamics is just the starting point. We often achieve a MAP > 65 mmHg, yet the patient persists with organ dysfunction. This 2025 review breaks down why this disconnect occurs and proposes treating real perfusion, not just arterial pressure. 🔎 Key Findings: 📊 True Perfusion Pressure: Tissue Perfusion Pressure (TPP) is defined as the gradient between MAP and the vessel's Critical Closing Pressure (Pcc). 🌊 Vasc