28K views · 611 reactions | This animation shows the ligand-gated ion channel GABA_A. GABA binds to the extracellular portion of the GABA_A receptor. This causes a conformational change of the GABA_A receptor which leads to the opening of the channel. Chloride ions (green) can then rush into the cell. | Ribosome Studio | Facebook

472K views · 7.7K reactions | The GABA-A receptor is a protein complex made of five subunits that acts as the brain's main brake, receiving inhibitory signals from neurons. When the neurotransmitter GABA binds, it opens a channel, allowing chloride ions to flow into the cell and quiet down its electrical activity. | Ribosome Studio | Facebook

#Neurociencias: Receptores GABA y traducción de la señal 🧠 La inhibición neuronal depende de cómo los receptores GABA transforman una señal química en efectos eléctricos y bioquímicos precisos. 🔹 Los receptores convierten la unión del GABA en cambios funcionales dentro de la neurona. 🔹 La inhibición no es un interruptor binario, sino un sistema graduado y contextual. 🔹 Diferentes tipos de receptores permiten ajustar intensidad, duración y alcance de la señal inhibitoria. 📌 La precisión del

The GABA-B receptor functions as a neuronal inhibitor, distinct from its counterpart, the GABA-A receptor. It operates as a G-protein-coupled receptor (GPCR), meaning that upon activation, it initiates a cellular signaling cascade rather than acting as a direct ion channel. When a signal molecule binds, the receptor releases its associated G-protein. The G-beta-gamma subunit then travels through the cell to activate a specific type of potassium channel called GIRK (G-protein-gated inwardly recti